How dangerous is CMM to the Irish population?
On average each year, about 375 new cases of malignant melanoma of the skin are diagnosed in Ireland each year, 235 in females, and 140 in males. Every year about 60 people in Ireland die of CMM, of these about 32 are female and 28 are male. This makes CMM the 6th most frequent category of malignant cancer in females, but only the 12th most frequent in males. European-age-standardised rates show it is also significantly higher among females than males, by about 52%. On average, an Irish female is estimated to have a 1-in-100 chance of developing this cancer by age 74, while males a 1-in-150 chance. CMM is now the most common cancer amongst Irish women aged 20-29 years. Irish females also have the third highest number of cases of this form of skin cancer in the EU, while Irish males have the sixth highest out of 15 other European nations. (EUCAN study Ferlay et al 1999). Rates of CMM amongst males in Northern Ireland are significantly higher than males in RoI (about 14%). Within the EU, a north-south gradient is evident with melanoma rates higher in the more northerly countries, especially Sweden. This is consistent with the hypothesis that intermittent sunlight exposure in sun-sensitive individuals may be a critical factor in melanoma development.
The condition becomes a significant cancer from about age 20 or 25 onwards and based on All-Ireland data, rates appear to rise gradually to about age 50, with a steeper increase in rates thereafter, reaching a peak in age-classes from 75 years onwards. Rates are substantially higher among females than males in all age-classes between 15 and 69 years, especially in the range 15-34 years. Although patterns are broadly consistent between NI and RoI, the age-profile of NI patients indicates, on average, earlier occurrence. It is interesting that mortality rates with European Age Standardised Incidence Rates (EASRs) do not differ significantly between males and females, despite higher incidence rates in females, thus reflecting lower average survival rates in males. On average, the risk of dying from melanoma of the skin in Ireland before age 75 is presently estimated to be 1 in 770 for women and 1 in 800 for men.
Risk Factors for Melanoma
Family history of melanoma
Dysplastic nevi
History of melanoma
Weakened immune system
Many ordinary moles (more than 50)
Ultraviolet (UV) radiation
Severe, blistering sunburns
Freckles
Fair skin Continue reading ‘The Increasing Incidence of Cutaneous Malignant Melanoma (CMM) In Ireland’ »